Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET
نویسندگان
چکیده
منابع مشابه
Solution Structure of Tensin2 SH2 Domain and Its Phosphotyrosine-Independent Interaction with DLC-1
BACKGROUND Src homology 2 (SH2) domain is a conserved module involved in various biological processes. Tensin family member was reported to be involved in tumor suppression by interacting with DLC-1 (deleted-in-liver-cancer-1) via its SH2 domain. We explore here the important questions that what the structure of tensin2 SH2 domain is, and how it binds to DLC-1, which might reveal a novel bindin...
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The solution structure and dynamics of G1TE, a nonphosphorylated cyclic peptide inhibitor for the Grb2 SH2 domain, was determined using two-dimensional NMR and simulated annealing methods. G1TE consists of 10 amino acids and a C-terminal Cys cyclized through its side-chain sulfur atom by a thioether linkage to its N terminus. The results indicate that G1TE assumes a circle-like shape in solutio...
متن کاملA phosphotyrosine interaction domain
A major step in the understanding of signal transduction came with the realization that Src homology 2 (SH2) domains bind peptide sequences containing phosphotyro-sine (Pawson and Schlessinger, 1993). Shc is an SH2 domain protein that becomes tyrosine phosphorylated after activation of cells by various cytokines and growth factors. This phosphorylation enables Shc to bind to Grb2, coupling Shc ...
متن کاملvalidation of a revised logical-mathematical intelligence scale and exploring its relationship with english language proficiency
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The SH2 domain interaction landscape.
Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines. Each domain displays a distinct preference for the sequence context of the phosphorylated residue. We have developed a high-density peptide chip technology that allows for probing of the affinity of most SH2 domains for a large fraction of the entire complement of tyro...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2018
ISSN: 0003-9861
DOI: 10.1016/j.abb.2018.08.012